At Mendus Pharmacy, we understand that choosing the right weight management medication is about more than just short-term results. Patients want long-lasting outcomes, minimal side effects, and a support system that helps them stay on track. As two of the leading options available today, Wegovy vs Mounjaro has become a key question for anyone considering long-term weight loss treatments.
Both medications are injectable GLP-1-based therapies, but they differ in formulation, clinical outcomes, and patient experiences. In this article, we’ll explore the pros and cons of each when it comes to long-term weight management, sustainability, and preventing weight regain.
Mechanism of Action and What That Means for You
Wegovy (semaglutide) is a GLP-1 receptor agonist, which means it mimics a hormone that helps regulate appetite and food intake. It slows gastric emptying, reduces cravings, and increases feelings of fullness.
Mounjaro (tirzepatide), on the other hand, is a dual agonist of both GLP-1 and GIP receptors. This combination targets appetite and energy balance in two ways, leading to more significant weight loss in many clinical trials.
While both work by curbing appetite, Mounjaro’s dual action may provide an added metabolic advantage—especially important for those with insulin resistance or type 2 diabetes.
Long-Term Effectiveness: What the Data Shows
Studies have shown Wegovy can help patients lose around 15% of their body weight over 68 weeks, provided they adhere to a supportive diet and lifestyle plan. Mounjaro has shown even more impressive results, with patients losing up to 20% or more in similar timeframes, depending on the dosage and patient profile.
However, the true challenge lies in maintaining that weight loss long-term.
Both medications require ongoing use to sustain results. If the treatment is stopped, studies suggest that most patients gradually regain weight—making long-term use a key consideration in your decision.
Pros of Wegovy for Long-Term Use
- Clinically proven safety profile: As the first GLP-1 analogue approved specifically for weight loss, Wegovy has a longer track record.
- Once-weekly dosing: This simple regimen helps improve compliance.
- Available through private and NHS channels: Wegovy is now accessible through select NHS weight management pathways in addition to private prescriptions.
- Helps with cardiovascular health: Recent data suggests cardiovascular benefits, especially for those with obesity-related conditions.
Cons of Wegovy
- Risk of weight regain after stopping: If lifestyle support is lacking, stopping Wegovy often leads to rebound weight gain.
- Gastrointestinal side effects: Nausea, constipation, and vomiting are common, especially early in treatment.
- Limited supply and availability: At times, Wegovy has been difficult to source due to high demand.
Pros of Mounjaro for Long-Term Use
- Greater average weight loss: Mounjaro outperforms Wegovy in many head-to-head comparisons.
- Dual hormone action: The additional GIP component may improve insulin sensitivity and metabolic function beyond GLP-1 alone.
- Potential to help break weight loss plateaus: Some patients who plateau on Wegovy see renewed progress with Mounjaro.
Cons of Mounjaro
- Not yet widely available in the UK: Mounjaro is newer to the UK market and access may be limited to private clinics at present.
- Higher cost: Due to its newer status and limited availability, Mounjaro can be more expensive.
- Similar gastrointestinal side effects: While effective, Mounjaro also carries a risk of nausea, diarrhoea, and reduced appetite.
Sustainability and Patient Support
Regardless of which medication you choose, long-term success depends on lifestyle changes and regular support. At Mendus Pharmacy, we provide a holistic programme alongside medication, including:
Dietary guidance: We offer resources to help you adopt a sustainable, balanced eating pattern that supports your medication.
Monthly check-ins: Regular pharmacist-led reviews to monitor weight, side effects, and adjust treatment plans.
Behavioural support: Access to referral partners such as dietitians, weight loss counsellors, or fitness coaches.
Education on adherence: Helping patients understand the importance of consistency in their treatment plan.
When weight loss is viewed as a chronic condition, rather than a one-off project, the need for ongoing support becomes clear. Stopping medication suddenly or without a tapering strategy can lead to biological responses that encourage rapid weight regain.
Wegovy vs Mounjaro: Which Is Right for You?
There is no one-size-fits-all answer. For some, Wegovy’s solid evidence base and growing NHS availability may make it the more practical choice. For others seeking more aggressive results or struggling with insulin resistance, Mounjaro might be the better fit—if access and cost are not barriers.
We recommend speaking to one of our pharmacists to assess your personal health profile, weight loss goals, and any other conditions you may have. We’re here to guide you through the pros and cons, ensure safe use, and provide the structure you need for sustainable success.
Contact Mendus Pharmacy today to learn more about Wegovy vs Mounjaro and discover which weight management solution suits your long-term journey.